Vitamin D metabolism in hypercorticism and acromegaly

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Abstract

Due to the high prevalence of low vitamin D levels in the overwhelming majority of regions of the world and discovery of extra-skeletal effects of vitamin D, the issue of maintaining adequate levels of vitamin D in the blood remains extremely relevant, especially in people with high risk of severe deficiency. To date, few studies have been performed on the features of vitamin D metabolism in disorders such as hypercorticism and acromegaly. However, vitamin D deficiency in such patients, according to available literature, may be more widespread and more pronounced than in general population. It is now recommended to use standard prophylactic and therapeutic doses of vitamin D for the treatment of these diseases, which may not satisfy the therapeutic goals specific to each disease. This review provides information on normal vitamin D metabolism, as well as literature data on the possible relationship and mutual influence between these endocrinopathies and vitamin D metabolism.

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About the authors

Alexandra A. Povaliaeva

Endocrinology Research Centre

Email: a.petrushkina@yandex.ru
M.D. Moscow

Ekaterina A. Pigarova

Endocrinology Research Centre

Email: kpigarova@gmail.com
M.D., Ph.D. Moscow

Larisa K. Dzeranova

Endocrinology Research Centre

Email: dzeranovalk@yandex.ru
M.D., Ph.D. Moscow

Liudmila Ya. Rozhinskaya

Endocrinology Research Centre

Email: lrozhinskaya@gmail.com
M.D., Ph.D., Professor Moscow

Galina A. Mel'nichenko

Endocrinology Research Centre

Email: teofrast2000@mail.ru
M.D., Ph.D., Professor Moscow

Valentina Aleksandrovna Peterkova

Email: peterkovava@hotmail.com

Sergey Anatol'evich Dogadin

Email: sadogadin@gmail.com

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Copyright (c) 2019 Povaliaeva A.A., Pigarova E.A., Dzeranova L.K., Rozhinskaya L.Y., Mel'nichenko G.A., Peterkova V.A., Dogadin S.A.

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