Association of adiponectin gene alleles with type 2 diabetes mellitus in residents of Bashkortostan

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Type 2 diabetes mellitus (T2DM) is one of the most acute problems of the modern world. The disease is characterized by high ratio of micro- and macrovascular complications. T2DM is a multifactorial and polygenic disease, structure of hereditary predisposition to which may be population-specific. Aim — the analysis of allelic associations of adiponectin gene (ADIPOQ, rs17366743) with T2DM, its clinical and metabolic characteristics and complications in T2DM patients resident in the Republic of Bashkortostan. Material and methods. 3 PCR-based method of genotyping with polymorphic marker rs17366743 of ADIPOQ gene in 433 T2DM patients and 428 healthy controls, residents of Bashkortostan. Results. The ratio of genotype CT and allele С was higher in T2DM patients compared with controls (15.7% vs. 6.8%; p=0.0002 and 7.8% vs. 3.4%; p<0.0001, respectively). Genotype ТТ and allele Т were less frequent in T2DM than in healthy subjects (84.3 and 93,2%; p=0.0002; 92.2 and 96.6%, p<0.0001, respectively). The association with the development of diabetic retinopathy and cataract was shown (p=0,044, p=0,008, respectively). Conclusions. Allele C and genotype CT are risk markers of T2DM (OR=2.43 and 2.56 respectively).

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About the authors

Diana S Avzaletdinova

Bashkir State Medical University

SPIN-code: 5540-6951
MD, PhD 450008, Ufa, Lenin street, 3

Liaisan F Sharipova

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences

SPIN-code: 6997-7627
graduate student of the department of endocrinology 71, Oktyabrya Ave., Ufa, Republic of Bashkortostan, 450054

Olga V Kochetova

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences

SPIN-code: 3461-3952
PhD 71, Oktyabrya Ave., Ufa, Republic of Bashkortostan, 450054

Tatiana V Morugova

Bashkir State Medical University

SPIN-code: 2976-9605
MD, PhD, Professor 450008, Ufa, Lenin street, 3

Olga E Mustafina

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences

SPIN-code: 5757-8712
PhD, Professor 71, Oktyabrya Ave., Ufa, Republic of Bashkortostan, 450054


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Copyright (c) 2020 Avzaletdinova D.S., Sharipova L.F., Kochetova O.V., Morugova T.V., Mustafina O.E.

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