Prospects of hydroxyapatite-based nanomaterials application synthesized by layer-by-layer method for pediatric traumatology and orthopedics

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The present brief review focuses on the features of the Layer-by-Layer (LbL) synthesis of coatings containing hydroxyapatite nanoparticles and assesses their use in solving several biomedical problems. This work provides the state-of-art of this field. This method is based on the sequential chemical adsorption of reagents on the substrate surface that makes it possible to apply nanolayers of the specified composition on the surface of a wide range of substrates of complex shape, to control the thickness of the synthesized layers accurately at the nanometer level. It also enables the modification of surface characteristics, including roughness, hydrophilicity, and surface charge, and allows “artificially” constructed multilayers consisting of hybrid organic and inorganic substances to be obtained. The experimental material presented in the review demonstrates the effectiveness of LbL synthesis for creating new 3D scaffolds as bone substitutes, coatings on the surface of metal implants, and drug delivery systems. A promising direction for the development of LbL synthesis is the creation of methods that involve ion-substituted hydroxyapatites as reagents. Success in this area can pave the way for significant advances in biomedicine and open new opportunities for creating a new generation of structures that mimic the structural, compositional, and mechanical properties of the bone mineral phase.

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About the authors

Aleksandra A. Meleshko

Institute of Chemistry St. Petersburg State University

PhD in Technical Sciences, Researcher 198504, St. Petersburg, Petergof, Universitetskii prospect 26

Valeri P. Tolstoy

Institute of Chemistry St. Petersburg State University

D.Sc. in Chemistry, senior researcher, Professor 198504, St. Petersburg, Petergof, Universitetskii prospect 26

Gennady E. Afinogenov

Saint Petersburg State University

MD, PhD, D.Sc., Professor, Professor of the Department of Oral and Maxillofacial Surgery and Surgical Dentistry 7/9, Universitetskaya embankment, Saint-Petersburg, 199034

Aleksandra S. Levshakova

Institute of Chemistry, Saint Petersburg State University

graduate student 198504, St. Petersburg, Petergof, Universitetskii prospect 26

Anna G. Afinogenova

Saint Petersburg State University; Saint Petersburg Pasteur Research Institute of Epidemiology and Mictobiology

Professor of the Department of Oral and Maxillofacial Surgery and Surgical Dentistry; D.Sc. in Biology, Senior Research Associate 7/9, Universitetskaya embankment, Saint-Petersburg, 199034; 14, Mira street, Saint Petersburg, 197101

Vladislav P. Muldiyarov

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

MD, Clinical Resident 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603

Sergei V. Vissarionov

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

MD, PhD, D.Sc., Professor, Corresponding Member of RAS, Deputy Director for Research and Academic Affairs, Head of the Department of Spinal Pathology and Neurosurgery 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603

Stanislav A. Linnik

North-Western State Medical University named after I.I. Mechnikov

MD, PhD, D.Sc., Professor, Professor of the Department of traumatology and orthopedics 41, Kirochnaya street, Saint-Petersburg, 191015

Yuriy Alekseevich Lapkin


Evgeniy Vladimirovich Zinov'ev



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Copyright (c) 2020 Meleshko A.A., Tolstoy V.P., Afinogenov G.E., Levshakova A.S., Afinogenova A.G., Muldiyarov V.P., Vissarionov S.V., Linnik S.A., Lapkin Y.A., Zinov'ev E.V.

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