Kisspeptins Regulation of male sex development: focus on diagnostic and therapeutic opportunities of delay of puberty and hypogonadotropic hypogonadism

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Abstract

Background. Kisspeptins, ligands of G protein–coupled receptor 54 ( KISS1R) encoded by the KiSS-1 gene, have recently emerged as key players of the gonadotropic axis.

It was found that KiSS-1/ KISS1R system plays an important role in the neuroendocrine control of gonadotropin secretion, brain sex differentiation, puberty onset and fertility.

Objective To investigate   the possible  relation between the serum level of kisspeptin and different stages of puberty in healthy boys and boys with delay of puberty onset  and hypogonadotropic hypogonadism. 

Methods. 43 boys in total were examined. They were divided into  three groups. Group 1 (boys aged 14-17 years with delay of puberty and hypogonadotropic hypogonadism, n=12). Group 2 (control, boys aged 14-18 years with normal puberty, Tanner stages IV-V, n=16). Group 3 (control, prepubertal boys aged 6-10 years, Tanner stage I).

Results. The level of kisspeptin in blood in group 2 and 3 did not have any differences (14,12 + 1,5 pg/ml and 16,27 + 1,44  pg/ml respectively, p>0,05). Unlike the above, the level of kisspeptin in group 1 was significantly higher than in both groups 2 and 3 (43,65 + 9,8 pg/ml  as opposed to 16,27+1,44 pg/ml,   p<0,01; 43,65 + 9,8   pg/ml  as opposed to 14,12+1,5 pg/ml, p<0,01 respectively).

Conclusions. The serum level of kisspeptins was found to be equal in boys, sexually developed regardless of their age and stage of puberty.  In contrast, the level of kisspeptins was significantly higher in boys affected with gonadotropic hypogonadism.  It can be caused by  KISS1R insensitivity or loss of biological activity of kisspeptin. The latter condition can be corrected by novel therapeutic technologies such as treatment with exogenous kisspeptin

About the authors

Irina Nikitina

ФГБУ  «Национальный  медицинский исследовательский центр им. В.А. Алмазова» МЗ РФ

Author for correspondence.
Email: nikitina0901@gmail.com

д.м.н.,  заведующая кафедрой детских болезней, зав. НИЛ детской эндокринологии

Russian Federation, 197341,  Санкт-Петербург, Аккуратова, 2

Yulia Yuchlina

«Национальный медицинский исследовательский центр им. В.А. Алмазова» МЗ РФ

Email: dom-j@mail.ru
ORCID iD: 0000-0001-9144-0578

ассистент кафедры детских болезней, м.н.с. НИЛ детской эндокринологии, сотрудник отделения детской эндокринологии

Russian Federation, 197341,  Санкт-Петербург, Аккуратова, 2

Irena Nagornaya

Email: irena_nagornaya@mail.ru

Elena Vasileva

Email: elena-almazlab@yandex.ru

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