Androgen sensitivity - beyond the well-known: literature review.

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Abstract

The attention of researches in recent years has been attracted to the study of gonadal and extragonadal effects of testosterone in men. One of the mechanisms via the effects of T may be implemented is the CAG repeat polymorphism within the androgen receptor gene, conditioning androgen sensitivity. In this review, we extensively discuss the literature data on the effect of polymorphism of the androgen receptor gene on embryogenesis and sex differentiation, regulation of spermatogenesis, progression of prostatic cancer and benign prostatic hyperplasia, hypogonadism, control of carbohydrate and lipid metabolism, bone mineral density, endothelial function, response on testosterone replacement therapy, as well as psycho-social aspects of a man's personality.

About the authors

Irina Khripun

State Educational Institution of Higher Professional Education "Rostov State Medical University" Ministry of Health of Russia

Author for correspondence.
Email: khripun.irina@gmail.com
ORCID iD: 0000-0003-0284-295X
SPIN-code: 8630-4828

MD, PhD, associate professor, department of endocrinology

Russian Federation, 344022, Nahichevanskiy str.29, Rostov-on-Don

Sergey Vorobyev

State Educational Institution of Higher Professional Education "Rostov State Medical University" Ministry of Health of Russia

Email: endocrinrosov@mail.ru
ORCID iD: 0000-0001-7884-2433
SPIN-code: 9773-6100

MD, PhD, professor, chair of endocrinology

Russian Federation, 344022, Nahichevanskiy str.29, Rostov-on-Don

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