On the connection of diabetes mellitus type 2 with air pollution by particulate matter

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Abstract

We review the contemporary literature data about the connection of air pollution by particulate matter (PM) with diabetes mellitus (DM) type 2 depending on their size, origins, chemical composition, and concentration in air by using the PubMed and RSCI databases. Traffic-related PMs, which contains transition metals, are recognized as most dangerous. Long-term exposure to high concentrations of fine and ultrafine PM is associated with increased risk of morbidity and mortality from DM type 2. Short-term exposure to PM causes the oxidative stress in lungs that leads to vascular insulin resistance and inflammation. PM-induced oxidative stress is the central trigger of inflammatory reactions leading to development of systemic inflammation. Exposure to fine PMs considerably increases expression of proinflammatory genes and corresponding signaling pathways. Numerous experimental studies and mathematical models confirmed capability of PM to unbalance glucose homeostasis, increase inflammation in adipose tissue, liver, and central nervous system. Up to date, the role of PM in the pathogenesis of DM type 2 is not clear, and the entire scheme of underlying molecular and cellular interactions has not been completed so far. Application of the formalized description approach to reconstruction of the PM-related network will help to reach better understanding of the air pollution role in the pathogenesis of human diseases, particularly, DM type 2. This understanding can facilitate to improve the existing therapies and preventive medicine.

About the authors

Alla Fedorovna Kolpakova

Institute of Computational Technologies SB RAS

Author for correspondence.
Email: kolpakova44@mail.ru
ORCID iD: 0000-0001-5544-2744
SPIN-code: 6318-0028

Professor, MD, lead scientist of the laboratory of bioinformatics

Russian Federation, 630090, Russia, Novosibirsk, prosp. akad. Rzhanova, 6

Ruslan Nilievich Sharipov

'BIOSOFT.RU', Ltd; Novosibirsk State University

Email: shrus79@gmai.com
ORCID iD: 0000-0003-2182-5493
SPIN-code: 1214-2918

project manager; senior teacher

Russian Federation, 630058, Russia, Novosibirsk, ul. Russkaya, 41/1, off. 11; 630090, Russia, Novosibirsk, ul. Pirogova, 2

Oxana Anatolievna Volkova

Institute of Cytology and Genetics SB RAS

Email: ov@bionet.nsc.ru
ORCID iD: 0000-0003-3357-3297
SPIN-code: 8803-1300

PhD, researcher of the laboratory of gene engineering

Russian Federation, 630090, Russia, Novosibirsk, prosp. akad. Lavrenjeva, 10

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